Endocrine Abstracts

Background: It has recently been recognized that thyroid hormones may rapidly generate biological responses by nongenomic mechanisms that are unaffected by inhibitors of transcription and translation. The signal transduction pathways for these effects are just beginning to be defined.Aim: To examine the specific pathway via which T3 can activate Akt in pancreatic beta cells and to understand further the possible implication of a nongenomic action of T3 i...

Background: Mitotane,(o,p’-DDD)is a compound with potent adrenotoxic effect and is able to block cortisol synthesis by inhibiting 11β-hydroxylation and cholesterol chain cleavage. For these reasons, mitotane was widely used in the treatment of adrenocortical cancer. Nevertheless the biological mechanism induced by these treatments in this cancer cells remain unknown.Aim: To study whether the o,p’-DDD could increase the susceptibility to th...